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KMID : 0383820100680010001
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Tuberculosis and Respiratory Diseases
2010 Volume.68 No. 1 p.1 ~ p.5
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18F-FDG Positron Emission Tomography in Patients with Concomitant Malignancy and Tuberculoma
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Lee Jung-Cheol
Oh Yeon-Mok
Lee Sang-Do
Kim Woo-Sung
Kim Dong-Soon
Shim Tae-Sun
Ryu Jin-Sook
Choi Chang-Min
Park I-Nae
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Abstract
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Background: To analyze the result of 18F-FDG positron emission tomography (PET) in patients with a concomitant malignancy and tuberculoma in a tuberculosis (TB)-endemic area.
Materials and Methods : Twelve patients with a concomitant malignancy and tuberculoma, who underwent whole-body 18F-FDG PET, were evaluated retrospectively. The maximal standardized uptake values (SUVmax) of the malignancy and tuberculoma were compared. In 6 patients, 18F-FDG PET was repeated during the anti-TB treatment and the changes in SUVmax were analyzed.
Results: Of the 12 patients, 10 were male. The mean age was 67.2±7.9 years. Tuberculomas were located in the lung (n=10) and lymph nodes (n=2), and tumors were located in the lung (n=6), colon (n=3), stomach (n=1), ovary (n=1) and liver (n=1). Although the mean SUVmax of malignant lesions was higher than that of tuberculomas (5.2±3.2 vs 3.5±2.0), the difference was not significant. In 4 patients, the SUVmax was higher in the tuberculoma than the tumor. After anti-TB treatment in 6 patients, the mean SUVmax of the tuberculomas decreased significantly, from 3.5±2.0 to 1.6±0.9 (p=0.028).
Conclusion: In patients with a concomitant malignancy and tuberculoma, SUVmax alone could not differentiate between them. However, 18F-FDG PET may be useful in monitoring the response to anti-TB treatment.
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KEYWORD
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Positron-Emission Tomography, Neoplasms, Tuberculoma
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